He was born in Buenos Aires on 17 December 1936, the son of Italian immigrants. His father Mario was an accountant employed by the railways and his mother Regina Sivori was a committed wife dedicated to raising their five children. He graduated as a chemical technician and then chose the path of the priesthood, entering the Diocesan Seminary of Villa Devoto. On 11 March 1958 he entered the novitiate of the Society of Jesus. He completed his studies of the humanities in Chile and returned to Argentina in 1963 to graduate with a degree in philosophy from the Colegio de San José in San Miguel. From 1964 to 1965 he taught literature and psychology at Immaculate Conception College in Santa Fé and in 1966 he taught the same subject at the Colegio del Salvatore in Buenos Aires. From 1967-70 he studied theology and obtained a degree from the Colegio of San José.

On 13 December 1969 he was ordained a priest by Archbishop Ramón José Castellano.  On 31 July 1973 he was appointed Provincial of the Jesuits in Argentina, an office he held for six years. On 20 May 1992 Pope John Paul II appointed him titular Bishop of Auca and Auxiliary of Buenos Aires. On 27 May he received episcopal ordination from the Cardinal in the cathedral. He chose as his episcopal motto, miserando atque eligendo, and on his coat of arms inserted the ihs, the symbol of the Society of Jesus.

Not even nine months had passed when, upon the death of Cardinal Quarracino, he succeeded him on 28 February 1998, as Archbishop, Primate of Argentina and Ordinary for Eastern-rite faithful in Argentina who have no Ordinary of their own rite.

Three years later at the Consistory of 21 February 2001, John Paul ii created him Cardinal, assigning him the title of San Roberto Bellarmino.